通过饮食和遗传诱导的肥胖引起的卵巢微环境变化的细胞图谱
Yonghui Jiang1,2,3,4,5,6, Xueying Gao1,2,3,4,5,7,8, Yue Liu1,2,3,4,5
1Center for Reproductive Medicine, Shandong University, Jinan, 250012, China.
Science China. Life sciences
|September 18, 2023
概括
肥胖严重影响卵巢微环境 (OME). 不同于高脂肪饮食肥胖症,瘦素消化肥胖症会改变卵巢细胞比例,扰乱卵泡发育,影响女性生育能力.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 基因组学就是基因组学.
背景情况:
- 肥胖与生殖系统损伤有关,但其对卵巢复杂微环境 (OME) 的影响尚未完全理解.
- 卵巢依赖于异质细胞类型来实现正常功能和女性生育能力.
- 了解肥胖对OME的影响对于解决生殖健康问题至关重要.
研究的目的:
- 研究不同类型的肥胖如何影响卵巢微环境 (OME).
- 在肥胖条件下分析卵巢内的细胞和空间变化.
- 确定导致肥胖的生殖功能障碍背后的分子机制.
主要方法:
- 卵巢的单细胞和纳米空间RNA测序.
- 高脂肪饮食 (HFD) 诱导的肥胖症和白清除 (OB) 诱导的肥胖症之间的比较.
- 对卵巢细胞类型比例,粒状细胞分化和基因表达模式的分析.
主要成果:
- 瘦素废除肥胖症 (OB),而不是HFD,改变了颗粒素的比例,theca-interstitial,luteal和内皮细胞.
- OB 干扰了壁膜颗粒细胞分化和毛囊发育.
- HFD增强了FSH敏感性和激素转化,而OB降低了敏感性和降低了类固醇激素转化,与Foxo1表达有关.
结论:
- 肥胖根据其原因 (HFD与OB) 不同地影响卵巢微环境.
- 瘦素消去肥胖症严重扰乱卵巢细胞动态和卵泡发育.
- 该研究提供了一个高分辨率的资源,以了解肥胖对女性生殖健康的影响.
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