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睡眠在22q11.2删除综合征:当前的发现,挑战和未来的方向

Kathleen P O'Hora^1,2, Charles H Schleifer^1,2,3, Carrie E Bearden^4,5

¹Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, 760 Westwood Plaza, Los Angeles, CA, 90095, USA.

Current psychiatry reports

|September 18, 2023

概括

睡眠障碍在22q11.2删除综合征 (22q11.2DS) 中很常见,影响健康和福祉. 对22q11.2DS睡眠的进一步研究可能会揭示新的治疗目标.

科学领域:

神经遗传学神经遗传学
睡眠医学睡眠医学
发展性精神病学是一个发展性精神病学.

背景情况:

22q11.2删除综合征 (22q11.2DS) 是一种神经遗传疾病,具有患精神病的高风险.
在22q11.2DS.DS患者中,经常报告睡眠障碍.

研究的目的:

在22q11.2DS.DS.中审查有关睡眠障碍的现有文献.
为了检查临床相关性和神经生物学基础的睡眠问题在这个人群中.

主要方法:

在22q11.2DS.DS.中对睡眠研究的文献评论.
专注于临床相关性和神经生物学因素.

主要成果:

睡眠障碍在22q11.2DS中普遍存在,并且与较差的健康结果有关.
由于方法上的挑战,关于睡眠架构和神经生理学的数据有限.

结论:

睡眠问题显著影响22q11.2DS.DS中的幸福感.
多模式睡眠评估是必要的,以了解神经生物学和确定治疗目标.

关键词:

22q11.2 这是一个很大的问题.自闭症自闭症自闭症副本数量变化的变化迪乔治综合征 (DiGeorge综合征) 是一种疾病.精神病谱系障碍精神病谱系障碍精神病谱系障碍睡眠睡眠睡眠睡眠睡觉的子是为了睡觉.快心脸部综合征快心脸部综合征

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