在帕金森病中与认知控制相关的前额叶皮质的连接性发生变化,伴有快速眼动睡眠行为障碍
Jinjing Liu1,2, Xiaoya Zou1, Jinming Gu3
1Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Brain imaging and behavior
|September 18, 2023
概括
与REM睡眠行为障碍 (RBD) 相关的帕金森病在前额叶区域显示出异常的大脑连接,这与认知缺陷有关. 这些发现表明帕金森病 (PD) 患者的功能连接 (FC) 发生变化,RBD患者可能是认知障碍的基础.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 快速眼动睡眠行为障碍 (RBD) 在帕金森病 (PD) 中很常见,但其潜在机制仍然不清楚.
- 前额叶皮层 (PFC),包括VLPFC,DLPFC和IFG,对于认知控制至关重要.
- 研究与RBD (PD-RBD) 的PD的功能连接 (FC) 和结构变化对于理解疾病病理生理学至关重要.
研究的目的:
- 在PD-RBD患者中探索异常功能连接 (FC) 和大脑体积变化.
- 确定RBD严重程度和神经成像发现之间的相关性.
- 调查改变的FC与PD-RBD中的认知功能之间的关系.
主要方法:
- 招募了20个PD-RBD,20个没有RBD的PD (PD-nRBD) 和20个正常的对照 (NC).
- 使用休息状态功能性MRI (rs-MRI) 来评估VLPFC,DLPFC和IFG中的FC.
- 在3D-T1结构MRI上使用基于voxel的形态学,用于全脑体积分析.
主要成果:
- 与NC相比,PD-RBD患者的视觉空间/执行和注意力得分较低.
- 在PD-RBD中,RBDSQ得分与右DLPFC和PCC之间的FC正相关,以及左VLPFC和右下部区域之间的FC正相关.
- 在PD-RBD组内的认知子域中观察到异常的FC相关性.
结论:
- 在VLPFC和DLPFC中异常的FC可能与PD患者的RBD有关.
- 在DLPFC和IFG中改变的FC可能会导致PD-RBD中的认知障碍机制.
- 这些发现强调了前额叶皮层功能障碍在患有RBD和相关认知缺陷的PD中的作用.
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