黄:一种全球性病原体,已经在哥伦比亚扎根
Patricia Escandón1, Shawn R Lockhart2, Nancy A Chow3
1Grupo de Microbiología, Instituto Nacional de Salud, Bogotá, D.C., Colombia. pescandon@ins.gov.co.
Biomedica : revista del Instituto Nacional de Salud
|September 18, 2023
概括
冠状腺菌 (Candida auris) 是一种多药耐药性真菌,构成了全球健康威胁. 哥伦比亚的病例虽然可以治疗,但表现出越来越多的可纳耐药性,其中分离物属于IV类.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 公共卫生 微生物学
背景情况:
- 黄是一种新兴的多抗药性病原体,引起了严重的公共卫生问题.
- 它在表面上的持久性,皮肤殖民和医疗保健传播促进了侵入性感染.
- 2009年首次报告,由于C. auris侵袭性感染的增加,全球警报在2015年增加.
研究的目的:
- 为了分析哥伦比亚Candida auris的流行病学.
- 调查哥伦比亚C. auris分离物的抗真菌耐药性模式和分子特征.
主要方法:
- 审查2016年至2022年国家健康警报和病例报告.
- 对C. auris分离物的抗真菌敏感性测试.
- 全基因组测序用于分子流行病学分析.
主要成果:
- 到2022年,哥伦比亚报告了2000多起C. auris病例,从2016年C. haemulonii被错误识别开始.
- 哥伦比亚的分离物表现出抗真菌敏感性,与其他地方的泛耐药菌株不同,尽管流可纳耐药性正在增加.
- 全基因组测序将哥伦比亚分离物置于第IV类,与其他南美菌株一致.
结论:
- 黄代表了哥伦比亚日益增长的传染病挑战,报告有2000多例病例.
- 虽然治疗方案仍然可用,但不断增加的弗卢可纳抗性需要持续监测.
- 分子数据证实哥伦比亚C. auris属于IV类,有助于区域流行病学理解.
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