两名患有骨质疏松症的绝经后妇女的口服大麻素治疗:一系列病例
Justyna Kulpa1, Amy Harrison1, Lance Rudolph2
1Canopy Growth Corporation, Smiths Falls, Ontario, Canada.
Cannabis and cannabinoid research
|September 18, 2023
概括
大麻素 (CBD) 在患有骨质疏松症的绝经后妇女中耐受良好,减少了骨周转标志物. 对CBD进行进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 骨生物学 骨生物学 骨生物学
背景情况:
- Cannabidiol (CBD) 是一种非麻醉性大麻素,在骨重塑中具有潜在的作用,但对人类的数据很少.
- 有限的人类研究存在CBD对骨周转标记物的影响.
研究的目的:
- 探索口服大麻素 (CBD) 对绝经后妇女骨周转的影响.
- 评估CBD在这个人群中的安全性和耐受性.
主要方法:
- 一个涉及两个患有骨质疏松症的绝经后妇女的病例系列随机分配给每天服用100或300毫克口服CBD,持续12周.
- 血清骨质再吸收 (CTx) 和形成 (P1NP,BSAP,OC) 标志物的评估,安全措施,血CBD度和生活质量指标.
主要成果:
- CBD耐受性良好,没有任何不良事件或重大安全问题.
- 经过12周的CBD治疗后,骨循环标志物 (CTx,P1NP,BSAP,OC) 的显著减少被观察到.
- 在血中检测到CBD及其代谢物,并报告了良好的符合性.
结论:
- 口服CBD的使用耐受性很好,并且与绝经后妇女的骨周转率标志物减少有关.
- 这些发现支持大规模随机临床试验的必要性,以调查CBD的骨保护作用.
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