人类细胞数量和大小分布
Ian A Hatton1,2, Eric D Galbraith2,3, Nono S C Merleau1,4
1Max Planck Institute for Mathematics in the Sciences, Leipzig 04103, Germany.
概括
人类细胞的大小和数量显示出一个反向的关系,较小的细胞更多. 这种权衡确保每个细胞大小组均对身体的总细胞生物质作出同等贡献.
科学领域:
- 人类生物学 人类生物学
- 细胞生物学 细胞生物学
- 定量生物学的定量生物学.
背景情况:
- 细胞大小和数量对于生物体的生长和功能至关重要.
- 整个人体细胞大小和细胞计数之间的关系仍然未被研究.
- 了解这种关系是全面了解人类细胞组织的关键.
研究的目的:
- 在所有主要的人类细胞类型中正式检查细胞大小和细胞计数之间的关系.
- 编制一个关于人类细胞大小和数量的综合数据集.
- 建立人类细胞组织的定量框架.
主要方法:
- 从1500多个已出版的来源收集数据.
- 分析了代表性男性,女性和儿童身体的主要细胞类型的细胞大小和数量.
- 开发了一个层次化的接口来访问蜂数据 (https://humancelltreemap.mis.mpg.de/).
主要成果:
- 估计的总细胞数量:约36万亿 (男性),约28万亿 (女性),约17万亿 (儿童).
- 发现细胞大小和细胞数量之间存在显著的反向关系.
- 证明了逻辑大小类中的细胞对总细胞生物质的贡献是平等的.
- 在细胞类型中观察到细胞大小调节,独立于平均细胞大小.
结论:
- 人体表现出细胞大小和细胞数量之间的权衡.
- 这种权衡导致不同细胞大小对生物质的持续贡献.
- 这些发现为人类细胞生物学提供了定量框架,并突出了大规模的生物模式.
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