在慢性鼻炎的非2型炎性内型中,病变发生十年的进展:2012-2022:慢性鼻炎的非2型炎性内型:2012-2022年
Na Cui1, Xuewei Zhu2, Chen Zhao2
1Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China, cuina@jlu.edu.cn.
International archives of allergy and immunology
|September 18, 2023
概括
非2型慢性鼻炎 (CRS) 的发病原因尚不清楚,但研究指出免疫机制和遗传因素. 了解这些通路对于开发针对性治疗这种异质上呼吸道炎症至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 基因组学就是基因组学.
背景情况:
- 慢性鼻炎 (CRS) 是一种复杂的上呼吸道炎症疾病,具有多种表型.
- 目前基于表型 (有或没有鼻) 的分类不充分反映了潜在的疾病机制.
- 基于内型的分类,特别是区分2型和非2型炎症,正在成为研究重点.
研究的目的:
- 批判性地分析最近关于CRS非2型炎症病原学的文献.
- 探索免疫学和分子方法来了解非2型CRS.
- 解决非2型CRS的异质性和影响因素.
主要方法:
- 在PubMed和Web of Science数据库中对过去十年发表的研究进行全面的文献搜索.
- 对研究的批判性分析,重点是非2型CRS的病变发生.
- 审查来自免疫学,基因组学和蛋白质组学的证据.
主要成果:
- 在CRS中驱动非2型炎症的精确机制尚未完全理解.
- 免疫学观点,基因组学和蛋白质组学为病变发生提供了新的见解.
- 非2型内型的患病率在地理和种族上有所不同,在亚洲人群中更为普遍.
- 鼻腔粘膜的微血管和淋巴干扰有助于炎症和组织重塑.
- 需要进一步调查CRS和SARS-CoV-2感染风险和病理生理学的关系.
结论:
- 需要进一步的研究来阐明非2型CRS的发病因子.
- 了解内型特异性机制对于个性化治疗策略至关重要,包括生物选择.
- CRS的异质性需要先进的分类和治疗方法.
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