英格兰梅毒的基因组流行病学:基于人口的研究
Mathew A Beale1, Louise Thorn2, Michelle J Cole3
1Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.
The Lancet. Microbe
|September 18, 2023
概括
对Treponema pallidum的全基因组测序确定了与英格兰梅毒传播网络相关的独特亚系. 这种基因组方法增强了对同性恋,双性恋和其他与男性发生性关系的男性 (GBMSM) 和异性恋人口中梅毒传播的理解.
科学领域:
- 基因组流行病学基因组流行病学
- 传染病监测 传染病监测 传染病监测 传染病监测
- 公共卫生微生物学
背景情况:
- 自2012年以来,英格兰的梅毒率显著增加,特别是在同性恋,双性恋和其他与男性发生性关系的男性 (GBMSM) 中.
- 人们对GBMSM和异性恋网络之间的传输动态仍然不太了解.
- 全基因组测序 (WGS) 提供了关于梅毒传播的增强流行病学见解的潜力.
研究的目的:
- 调查全基因组测序对理解英格兰梅毒传播的有用性.
- 识别不同的Treponema pallidum亚系及其与不同性网络的关联.
- 为了补充流行病学数据,为公共卫生干预提供基因组见解.
主要方法:
- 来自英格兰的237个Treponema pallidum全基因组的家族基因组分析 (2012-2018).
- 将基因组数据与患者的人口,地理空间和行为元数据联系起来.
- 聚类分析以确定传播模式和亚系.
主要成果:
- 在英格兰确定了两个主要的Treponema pallidum亚系.
- 亚系1在所有群体和地区普遍存在,而亚系14主要在34岁以上的GBMSM中发现,并且在北英格兰不存在.
- 基因组数据区分了当地异性传播集群与GBMSM的背景传播.
结论:
- 基因组学可以识别假定梅毒传播集群,尽管Treponema pallidum的全球遗传相似性很高.
- 这种方法可以帮助解开疫情的复杂性,并为有针对性的公共卫生干预提供信息.
- 世界梅毒统计系统为梅毒传播动态提供了有价值的流行病学见解.
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