在患有自闭症,发育迟缓或发育典型的儿童中比较胃肠内镜检查结果
Sonia A Ballal1, Saige Greenwell1, Enju Liu2
1Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA.
The Journal of pediatrics
|September 18, 2023
概括
与对照组相比,患有自闭症谱系障碍 (ASD) 的儿童患食道炎症,特别是食道炎的比率增加. 上部内镜 (EGD) 对于在ASD患者中诊断这些疾病至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 儿科胃肠病学 儿科胃肠病学
- 自闭症谱系障碍研究研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种影响社会互动和沟通的神经发育状况.
- 患有自闭症儿童经常报告胃肠道 (GI) 问题,但对内镜检查结果的比较数据有限.
- 了解这些差异对于ASD儿童的综合护理至关重要.
研究的目的:
- 为了比较ASD儿童的上部内镜 (食管胃二透镜 (EGD)) 和组织学发现.
- 将这些发现与年龄和性别匹配的对照进行对比,以发育迟缓 (DD) 或典型发育 (TD).
主要方法:
- 一项回顾性,横截面研究,涉及2104名接受EGD的儿童.
- 患者被分为ASD,DD和TD组 (1:1:2比).
- 统计分析 (基平方,费舍尔精确测试,多变量线性回归) 比较了EGD发现和鉴定的组织学预测因子.
主要成果:
- 患有自闭症的儿童表现出异常食道组织学,特别是食道炎的比率更高 (38.4%与33.4%DD,30.4%TD相比;P=.008).
- 自闭症诊断是异常食道组织学的独立预测因素 (OR 1.38).
- 没有观察到胃部发现的显著差异;十二指管异常在ASD中较少发生 (17.0%对20.1%DD,24.2%TD;P=.005).
结论:
- 与对照组相比,患有自闭症儿童的组织性食道炎的患病率显著更高.
- 自闭症是异常食道组织学的独立预测因子,强调了EGD在这个人群中的重要性.
- 进一步的研究可能会探索连接ASD和食道病理的潜在机制.
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