针对COVID-19的治疗方法
Hayden S Andrews1, Jonathan D Herman2,3, Rajesh T Gandhi1
1Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; email: hsandrews@mgh.harvard.edu, rgandhi@mgh.harvard.edu.
Annual review of medicine
|September 18, 2023
概括
现在,COVID-19的治疗方法集中在早期的,不那么严重的疾病的抗病毒药物和关键病例的免疫调节剂上. 新的试验性药物正在研究,以进一步发展治疗策略.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
背景情况:
- 自疫情爆发以来,COVID-19的治疗方法迅速发展.
- 目前的治疗策略主要涉及抗病毒和免疫调节剂.
研究的目的:
- 总结目前COVID-19治疗方法的情况.
- 突出不同治疗类别不断变化的作用.
主要方法:
- 审查当前的临床实践和COVID-19疗法的新兴研究.
- 对抗病毒和免疫调节剂的疗效和最佳时间的分析.
主要成果:
- 抗病毒药物 (例如,remdesivir,nirmatrelvir-ritonavir) 在早期和不那么严重的疾病中最有效.
- 免疫调节剂 (例如,德甲,IL-6/JAK抑制剂) 对严重和危急的疾病至关重要.
- 单克隆抗体由于病毒变异而降低了效用;康复期血缺乏共识.
- 抗血栓治疗尽管在COVID-19中增加了静脉血栓栓塞的风险,但其作用有限.
结论:
- 根据疾病严重程度,COVID-19的治疗是动态的,抗病毒药物和免疫调节剂的作用是不同的.
- 对实验药物的持续研究有望进一步完善治疗模式.
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