昼夜钟基因表达与年轻人和老年人的饮食时间之间的关联
Masaki Takahashi1, Mayuko Fukazawa2, Yu Tahara3
1Institute for Liberal Arts, Tokyo Institute of Technology, Tokyo, Japan.
Chronobiology international
|September 18, 2023
概括
最佳的饮食时间可能会影响昼夜钟基因表达,特别是在老年人中. 从睡前到早餐的更长的禁食和早起后的早餐与年轻人和老年人的强大的时钟基因节奏相关.
科学领域:
- 时间生物学 时间生物学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 衰老与昼夜时钟系统的衰退有关,可能导致与年龄相关的疾病.
- 慢性营养探讨了饮食时间和昼夜节律之间的相互作用.
- 对于调节人类昼夜钟的最佳饮食时间尚不清楚.
研究的目的:
- 研究年轻人与老年人的时钟基因表达和饮食时间之间的关系.
- 为了确定年龄组之间的昼夜节律和食时间模式的潜在差异.
主要方法:
- 对51名年轻和35名年长的健康男性进行了横截面研究.
- 胡须毛囊细胞在24小时内每4小时收集一次,以评估时钟基因表达.
- 参与者记录了睡眠,觉醒和饮食时间,以计算禁食和饮食间隔.
主要成果:
- 与年轻成年人相比,老年人在6点钟表达NR1D1和PER3显著更高.
- 对于NR1D2和PER3的峰值表达时间在各年龄组之间有显著差异.
- 年长的成年人有更长的"睡觉时间到早餐"和更短的"晚餐到睡觉"间隔.
- 在年轻成年人中,较高的NR1D1节律与更长的禁食和更短的起床至第一餐间隔相关.
- 在老年人中,更高的PER3节律与更长的"睡前到早餐"间隔相关.
结论:
- 在老年人中,时钟基因表达峰值可能处于发达阶段.
- 更长的禁食时间 (从睡觉到早餐) 和早起后更早的进食可能会支持强大的时钟基因表达节奏.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
02:45Biological Clocks and Seasonal Responses
34.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.7K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
87
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
87
01:26Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86