在接受免疫检查点抑制剂治疗的患者中,眼睛表面的定量变化
Kevin Chen1, Maria Carolina Ibañez Bruron2, Sebastian Mondaca3
1Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Ocular immunology and inflammation
|September 18, 2023
概括
免疫检查点抑制剂 (ICI) 治疗可以导致眼睛表面的变化,包括干燥. 像人工眼和皮质类固醇这样的治疗方法可以帮助在接受ICI治疗的患者中稳定这些情况.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于癌症治疗.
- 眼表面并发症是ICI治疗的潜在副作用.
- 了解这些影响对于患者管理至关重要.
研究的目的:
- 描述接受ICI治疗的患者眼表面变化的临床过程.
- 评估各种治疗方法对这些眼睛表面疾病的有效性.
主要方法:
- 在16名接受ICI治疗的患者中,对多个眼睛表面干燥标记物的评估.
- 使用威尔科克森等级和试验进行统计分析,以评估眼睛表面指数的变化.
- 治疗干预措施的评估,包括人工眼,环素,皮质类固醇,温暖的压缩剂和点滴塞.
主要成果:
- 50%的眼睛显示了施尔默I分数的恶化,29%的眼睛增加了利萨明绿色染色.
- 43%的患者在眼睛表面疾病指数 (OSDI) 得分下降.
- 常见的治疗方法包括人工眼 (88%),环素 (25%) 和局部皮质类固醇 (31%).
结论:
- 许多接受ICI治疗的患者会出现眼睛表面变化.
- 在这种患者群体中,医疗干预可以有效地稳定眼表面疾病.
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