支气管支气管洗对免疫受损宿主管理的影响
Kathleen Jahn1, Meropi Karakioulaki2, Desiree M Schumann1
1Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital, Basel, Switzerland.
支气管支气管洗 (BAL) 显著改变了疑似下呼吸道感染的免疫受损患者的治疗. 这种诊断程序揭示了病毒和多微生物感染的高患病率,影响了患者的治疗结果.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 呼吸道感染对免疫受损的个体构成重大风险.
- 带有支气管洗 (BAL) 的光纤支气管镜检查对于诊断这一群体感染至关重要.
- 下呼吸道感染 (LRTI) 需要及时和准确的诊断在免疫功能低下的患者.
研究的目的:
- 评估BAL对临床管理决策的影响.
- 评估BAL在疑似LRTI的免疫受损患者的诊断产量.
- 在这个患者群体中确定各种传染病原体,包括病毒病原体的流行率.
主要方法:
- 在免疫功能低下患者的诊断BAL程序的回顾性分析.
- 包括疑似LRTI和免疫抑制 (血液学,固体器官移植,其他) 的患者.
- 评估管理变化和BAL.post后的30天结果.
主要成果:
- 在52.36%的案例中,BAL导致了管理层的变化.
- 在免疫抑制类别中观察到管理变化和30天死亡率的显著差异.
- 呼吸道病毒病原体经常被识别为单个或多个感染.
结论:
- BAL是一种关键的诊断工具,经常指导免疫功能低下患者的治疗调整.
- 在这个脆弱的人群中,多微生物和病毒性呼吸道感染很常见.
- 确定的特定病毒病原体会影响患者的预后和不良结果的风险.
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