治疗动脉样硬化心血管疾病的性别差异
Jessica N Holtzman1, Gurleen Kaur2, Breanna Hansen3
1Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Atherosclerosis
|September 18, 2023
概括
与男性相比,女性在动脉样硬化心血管疾病 (ASCVD) 诊断,治疗和结果方面面临着持续的差异. 解决这些基于性别的差异和改善护理对于改善女性心血管健康至关重要.
科学领域:
- 心脏病学 心脏病学
- 心血管疾病研究研究
- 基于性别的健康差异
背景情况:
- 女性和男性之间在动脉样硬化心血管疾病 (ASCVD) 的诊断,治疗和预后方面存在持续的差异.
- 尽管人们越来越关注基于性别的差异,但短期和长期的心血管结果仍然不平等.
- 这些差异需要对影响各种急性冠状动脉综合征 (ACS) 和非阻塞性冠状动脉心肌梗塞 (MINOCA) 治疗的病理生理学变异进行调查.
研究的目的:
- 审查现有关于女性和男性之间的差异性治疗指南,护理实施和心血管结果的现有数据.
- 突出年龄作为影响修饰剂对年轻女性ACS结果的影响.
- 确定未来的研究方向,以改善女性的心血管护理.
主要方法:
- 对ASCVD中基于性别的差异现有数据的文献综述.
- 分析不同急性冠状动脉综合征 (ACS) 的治疗模式和结果.
- 考虑年龄作为心血管事件的修饰因素.
主要成果:
- 被诊断患有ACS的年轻女性在医院死亡率和主要心血管不良事件的高.
- 妇女在临床试验中的代表性不足阻碍了基于证据的治疗实施.
- 证据支持心血管药物的疗效和安全性,在整个ACS谱的女性.
结论:
- 解决ASCVD的性别差异对于改善心血管保健至关重要.
- 以患者为中心和系统层面的干预措施对于提高结果至关重要.
- 需要进一步的临床研究来弥合女性心血管保健方面的差距.
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