患有复发性和慢性胰腺炎的儿童的骨健康:多中心横截面分析
Maisam Abu-El-Haija1, Lindsey Hornung2, Kate Ellery3
1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
概括
与健康儿童相比,患有急性复发性胰腺炎 (ARP) 或慢性胰腺炎 (CP) 的儿童的生长受损,骨矿物质密度 (BMD) 较低. 监测这些儿科患者的骨健康至关重要.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 胰腺炎儿童的骨健康状况尚未得到充分研究.
- 急性复发性胰腺炎 (ARP) 和慢性胰腺炎 (CP) 显著影响儿科健康.
- 关于儿科胰腺炎患者的生长和骨矿物积累的数据有限.
研究的目的:
- 为了调查诊断为ARP或CP的儿童的骨健康状况.
- 为了比较小儿胰腺炎患者的身高和骨矿物质密度 (BMD) 与健康对照.
- 为了确定这一群体在生长和骨矿物质获取方面的潜在缺陷.
主要方法:
- 使用INSPPIRE-2注册表中的数据进行回顾性研究设计.
- 包括87名患有ARP (53%) 和CP (47%) 的儿科患者的数据.
- 使用DXA扫描评估年龄的身高和高度调整的骨矿物密度 (BMD).
主要成果:
- 在研究队列中,低身高 (Z-score < -2) 的患病率为13%.
- 低身高调整的BMD (Z-score < -2) 的患病率为6.4%.
- 低身高相对于年龄和低骨质量均显著高于健康参考人群 (p < 0.0001和p = 0.03分别).
结论:
- 与健康同龄人相比,被诊断患有ARP或CP的儿童的身高和骨质量显著下降.
- 在患有胰腺疾病的儿童中,生长和骨矿物质积累缺陷很普遍.
- 对患有胰腺炎的儿科患者来说,监测生长和骨健康的临床关注是必不可少的.
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