[肝纤维化查,评估途径和脂肪肝患者的治疗]
1Department of Hepatology, Center for Fatty Liver, Tianjin Second People's Hospital, Tianjin Research Institute of Liver Diseases, Tianjin 300192, China.
非酒精性脂肪肝 (NAFLD) 存在风险,特别是晚期纤维化. 本综述侧重于非侵入性测试 (NIT),用于查和管理中国高风险NAFLD患者的肝纤维化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医学诊断 医学诊断 医学诊断
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 可以发展为非酒精性脂肪性肝炎 (NASH),并出现显著的肝纤维化 (F2-F4).
- 晚期纤维化 (F2-F4) 患者面临肝脏相关并发症和死亡的风险增加.
- 中国庞大的NAFLD人口需要有效的肝纤维化查.
研究的目的:
- 审查目前在NAFLD患者中检测肝纤维化的非侵入性测试 (NIT).
- 提出查,评估和管理策略,以此种人群肝纤维化.
- 根据最近的NIT进展,为NAFLD指导方针提供信息.
主要方法:
- 审查国内和国际预防和治疗NAFLD的指导方针.
- 对肝纤维化非侵入性测试 (NITs) 的最新研究进展进行分析.
- 综合发现,建议NAFLD肝纤维化患者的临床途径.
主要成果:
- 确定了血清学模型,振动控制的短暂弹性图像和磁共振弹性图像 (MRE) 作为目前肝纤维化NIT.
- 强调在中国的NAFLD人口中对肝纤维化进行有效查的必要性至关重要.
- 强调将NIT纳入NAFLD管理战略的重要性.
结论:
- 非侵入性测试对于识别患有肝纤维化的有风险的NAFLD患者至关重要.
- 建议在NAFLD管理中使用NIT进行查和评估的结构化方法.
- 基于纤维化评估的及时干预可以减轻与肝脏有关的事件和死亡率.
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