空间转录学界定了肺腺癌进展中的分子特征和细胞可塑性
Yan Wang1, Bing Liu2, Qingjie Min1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
Cell discovery
|September 18, 2023
概括
这项研究揭示了肺腺癌 (LUAD) 组织学亚型进展的分子驱动因素. 它识别出独特的巨细胞群和缺氧驱动网络,为侵入性LUAD提供新的治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 肺腺癌 (LUAD) 呈现出共存的惰性和攻击性的组织学亚型.
- 在LUAD中亚型转换和异质性的分子基础在很大程度上是未知的.
研究的目的:
- 阐明不同的LUAD组织学亚型的分子特征和细胞可塑性.
- 确定与LUAD亚型进展相关的分子驱动因素和信号通路.
主要方法:
- 空间转录学和多重免疫组织化学的整合.
- 对转录重编程和细胞信号传递动态的分析.
主要成果:
- 不同的LUAD组织学亚型在脱差状态中显示异质性.
- 低氧诱导的调节网络显著影响亚型的进展.
- 在每个LUAD亚型中,特定的瘤相关的巨细胞亚群被确定,可能会创造一个免疫抑制的微环境.
结论:
- 已经建立了一个全面的LUAD亚型进展的分子景观.
- 这些发现表明了侵入性LUAD的新型治疗策略和点,特别关注巨细胞的作用和缺氧通路.
相关概念视频
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K