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Updated: Jun 30, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
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全基因组选揭示了人类中性粒细胞分化状态和上下文依赖迁移的调节者

Nathan M Belliveau1, Matthew J Footer1, Emel Akdoǧan2

  • 1Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA.

Nature communications
|September 18, 2023
PubMed
概括

这项研究确定了影响中性粒细胞样细胞功能的关键分子因素,包括增殖,分化和迁移. 它突出了mTORC1的信号传输.

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Differentiation of Common Myeloid Progenitor Cells01:15

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...