变化的结直肠癌流行病学 - 出生队列效应和新出现的风险因素
Caitlin C Murphy1, Timothy A Zaki2,3
1Department of Health Promotion & Behavioral Sciences, University of Texas Health Science Center at Houston (UTHealth Houston) School of Public Health, Houston, TX, USA. caitlin.c.murphy@uth.tmc.edu.
Nature reviews. Gastroenterology & hepatology
|September 18, 2023
概括
结肠直肠癌 (CRC) 的发病率在全球范围内不断上升,特别是在年轻的出生群体中. 早期暴露和环境因素可能有助于这些趋势,需要识别新的风险因素和改进查.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 全球结直肠癌 (CRC) 的发病率和死亡率正在增加.
- 这一趋势表明CRC流行病学发生了重大变化,特别是在年轻人群中.
研究的目的:
- 根据年龄和出生队列,审查CRC发病率和死亡率的变化.
- 探索早期暴露和新兴风险因素在这些流行病学转变中的作用.
主要方法:
- 综述结直肠癌的流行病学趋势.
- 根据年龄和出生队列分析发病率和死亡率数据.
- 综合关于早期暴露和环境因素的证据.
主要成果:
- 结肠直肠癌的发病率在全球上升,自20世纪50年代初出生的人.
- 出生队列效应表明影响整个寿命的早期致癌的因素.
- 早期的暴露 (胎儿发育到年轻成人) 和环境化学物质都与此有关.
结论:
- 扭转全球CRC负担需要更多地参与查计划.
- 识别新出现的风险因素对于应对不断上升的结直肠癌率至关重要.
- 有证据表明,早期生活和环境因素是CRC发病率增加的关键驱动因素.
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