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线粒体健康指数与双极性障碍中血循环的无细胞线粒体DNA相关

Rafaela C Cordeiro¹, Camila N C Lima¹, Gabriel R Fries^1,2,3,4

¹Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Molecular psychiatry

|September 18, 2023

概括

线粒体功能障碍,或线粒体全静电负荷,与双相情感障碍 (BD) 有关. 在BD患者中,较低的线粒体健康与疾病严重程度和较差的结果相关,这表明线粒体是治疗点.

科学领域:

神经科学是一个神经科学.
细胞生物学细胞生物学
精神病学是一个精神病学.

背景情况:

线粒体功能障碍与双相情感障碍 (BD) 病理生理学有关.
线粒体在应激适应,细胞弹性和全静电负荷方面发挥非能量作用.
线粒体全静电负荷发生在线粒体无法维持细胞平衡时.

研究的目的:

评估BD患者与对照患者的线粒体健康指数 (MHI).
调查MHI,无细胞线粒体DNA (ccf-mtDNA) 水平和BD的临床结果之间的关系.
探索MHI,ccf-mtDNA和线粒体质量控制 (MQC) 蛋白之间的联系.

主要方法:

从14名BD-I患者和16名对照中评估了PBMC中的MHI,酸盐合成酶和复合I,II,IV活动.
通过qPCR测量了血ccf-mtDNA水平.
通过使用西方抹黑评估MQC蛋白质 (Fis-1,Opa-1,LC3).

主要成果:

与对照组相比,BD患者表现出较低的MHI和较高的ccf-mtDNA水平,即使对共变量进行调整.
MHI与Fis-1负相关,与Opa-1和LC3正相关;ccf-mtDNA显示相反的相关性.
较低的MHI和较高的ccf-mtDNA与增加的疾病严重程度,更长的持续时间,更差的功能和BD中的抑郁症状相关.

结论:

线粒体全静电负荷有助于BD病理生理学.
线粒体是BD.中细胞弹性受损和压力脆弱性的潜在生物标.
线粒体功能障碍与BD进展和不良结果有关,可能作为预测标志物和治疗指南.

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