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增殖和非增殖细胞单层的拓性质和形状

Daria S Roshal¹, Karim Azzag², Kirill K Fedorenko¹

¹Physics Faculty, Southern Federal University, 344090 Rostov-on-Don, Russia.

Physical review. E

|September 19, 2023

概括

研究细胞单层揭示了它们的形状如何影响拓特征. 零拓电荷增加了邻近的概率,在球形和平面细胞排列之间观察到差异.

科学领域:

细胞生物学细胞生物学
生物物理学的生物物理.
发育生物学是发展生物学.

背景情况:

复杂的生物结构在胚胎发育过程中从简单的上皮单层中出现.
了解支配形态发生的生物物理定律对于研究生物系统至关重要.
表皮单层作为模型系统,用于研究形状转换及其潜在机制.

研究的目的:

研究子脏 (COS) 细胞单层的全球和本地拓特征.
确定细胞单层的形状 (球形与平面) 如何影响它们的拓性质.
为了比较繁殖的COS细胞单层与非繁殖的状卵细胞表皮的拓关系.

主要方法:

在球形和平面COS细胞单层中分析细胞价值分布.
研究细胞对拓电荷和邻近概率之间的关系.
在COS和ascidian上皮质的拓缺陷 (痕,折叠) 的比较分析.

主要成果:

在球形和平面COS细胞单层之间,细胞价值分布有显著差异.
细胞是最近邻居的概率受到细胞对的拓电荷的影响,零电荷增加了这种概率.
亚酸卵细胞上皮表现出非随机聚合的6价值细胞,并具有线性拓缺陷,与COS细胞单层不同.

结论:

表皮单层形状是其全球和局部拓特征的关键决定因素.
拓电荷在上皮细胞系统中的细胞与邻细胞相互作用中起作用.
细胞增殖和拓学的差异有助于在不同的上皮系统中产生不同的形态结果.

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