在雄性大鼠中,海马损伤会导致对物体的视觉,但不是气味,属性的逆行性失忆
Sean G Lacoursiere1, Brendan B McAllister1, Crystal Hadikin1,2
1Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada.
The European journal of neuroscience
|September 19, 2023
概括
在老鼠的海马体病变中,当视觉线索缺少时,物体区分记忆是免费的,但当气味线索被删除时,它会受到损害. 这表明长期的气味记忆,与视觉对象回忆不同,不依赖于海马.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 动物行为 动物行为
背景情况:
- 海马对记忆至关重要,但其在逆行性失忆症中的作用对于特定的记忆类型,如气味和物体歧视是有争议的.
- 关于海马病变和对物体/气味歧视的逆行性失忆症的先前研究受到潜在的海马节约和不受控制的气味线索的限制.
研究的目的:
- 为了研究海马在老鼠对象歧视记忆的逆行性失忆症中的作用.
- 为了确定气味或视觉线索是否对海马体损伤后遗留的对象区分记忆至关重要.
主要方法:
- 雄性大鼠被训练在一个物体歧视任务,有明显的视觉和气味线索.
- 神经毒性海马病变是使用N-甲基-D-酸盐 (NMDA) 诱导的.
- 鼠被测试在手术前学到的歧视与或没有视觉或气味线索,并训练在一个新的歧视任务损伤后.
主要成果:
- 在没有视觉线索 (在黑暗中) 进行测试时,具有显著海马病变 (平均87%) 的老鼠表现出保存的对象区分记忆.
- 然而,当从物体中删除明确的气味线索时,歧视性能受到损害.
- 虽然海马病变增加了新的学习标准的试验,但老鼠仍然可以解决术后歧视问题.
结论:
- 对气味的长期记忆,与对视觉对象属性的回忆不同,在老鼠中似乎独立于海马.
- 这些发现与之前的观察结果一致,表明海马损伤不会导致气味记忆的逆行性失忆症.
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