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从OptimAT研究中,在现实生活中的住院患者中观察到阿皮克萨班的群体药理动力学

Frédéric Gaspar1,2,3, Jean Terrier4,5,6, Samantha Favre1,2,3

  • 1Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

CPT: pharmacometrics & systems pharmacology
|September 19, 2023
PubMed
概括

在住院患者中,阿皮克萨班的药理动力学 (PKs) 显示出显著的变化,主要受到功能和P-糖蛋白 (P-gp) 活性的影响. 了解这些因素对于优化阿皮克萨班剂量和防止过度暴露至关重要.

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