使用同行工作者的C型肝炎"测试,追踪和治疗"试点项目有什么影响?
Allsop Caroline1, Mcque Kate1, Mark Roberts2
1Viral Hepatitis Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Journal of viral hepatitis
|September 19, 2023
概括
一个使用同行工作者测试型肝炎C病毒 (HCV) 接触者的试点计划发现接触者中活跃HCV的高发病率. 大多数检测阳性的人开始接受抗病毒治疗,帮助消除HCV的努力.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 慢性肝炎C病毒 (HCV) 感染仍然是全球健康的重大负担,导致广泛的发病率和死亡率.
- 到2030年消除HCV的目标需要创新的策略,特别是对于高风险人群,如注射毒品的人 (PWIDs).
- 对HCV的接触追踪并非常规实施,这表明在全面的HCV控制中存在差距.
研究的目的:
- 评估试点C型肝炎病毒 (HCV) "测试,追踪和治疗"计划的结果,利用同行工作者.
- 评估吸引注射毒品的个人 (PWIDs) 参与识别和测试他们接触HCV的可行性和有效性.
- 确定接触者中活跃的HCV感染的患病率和随后的治疗.
主要方法:
- 一项试点研究邀请被诊断出HCV的PWID参与"测试,追踪和治疗"倡议.
- 同行工作者聘请同意的参与者确定并邀请他们的潜在联系人进行HCV测试.
- 收集的数据包括参与率,HCV检测结果,治疗开始和不参与的原因.
主要成果:
- 在295个被邀请的个人中,有147人 (50%) 同意参与,有30人 (20%的同意者) 协助对120个接触者的测试.
- 在44名 (37%) 测试接触者中发现HCVRNA阳性,其中23例先前未被诊断的病例被确定.
- 在再次感染的接触者中,HCV RNA阳性是最高的 (45%),大多数 (77%) 的阳性接触者开始了抗病毒治疗.
结论:
- 该试点表明,将PWID参与到由同行领导的HCV"测试,追踪和治疗"计划中,可以识别大量活跃的HCV感染.
- 虽然参与率和接触者转诊率中等,但接触者中活跃HCV的高患病率强调了这种方法的价值.
- 这些发现支持将同行指导的接触追踪纳入HCV消除策略,特别是PWID网络.
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