根据年龄和遗传倾向获得的风险因素和发生的心房动
Ningjian Wang1, Yuefeng Yu1, Ying Sun1
1Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, No. 639 Zhizaoju Road, Huangpu District, Shanghai 200011, China.
European heart journal
|September 19, 2023
概括
了解心房动 (AF) 风险因素是预防的关键. 心脏代谢因素是主要的贡献者,其影响因年龄和遗传倾向而异,强调需要个性化AF预防策略.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 心房动 (AF) 是成年人中最常见的持续性心律失常.
- 调查不同年龄和遗传风险群体的AF风险因子概况对于个性化预防策略至关重要.
研究的目的:
- 检查与各种风险因素相关的发生性AF的人口归因风险 (PAR).
- 分析这些跨不同年龄组和遗传风险层的关联.
主要方法:
- 利用了来自409,661名没有基线AF的英国生物库队列数据.
- 评估了23个风险因素,包括社会,健康行为,心脏代谢和临床并发症,以及遗传风险评分 (GRS).
- 分析了三个年龄组 (40-69岁) 和三个遗传风险组 (低,中等,高GRS) 的危险比率和PAR百分比.
主要成果:
- 心脏代谢因素是发生性AF的最大贡献者 (PAR: 36.2%-41.9%),高血压和超重/肥胖是主要的可修改因素.
- 大多数心脏代谢因子/临床并发症和AF之间的关联在年轻年龄组中得到加强.
- 可归因于心脏代谢因素和临床并发症的AF风险随着遗传风险的增加而降低.
结论:
- 这项研究为英国成年人与年龄和遗传倾向相关的AF风险因素概况提供了全面的见解.
- 根据年龄和遗传倾向对风险因素进行分层,可以提高AF预防工作的精度和效率.
相关概念视频
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
40
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
40
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Factors affecting Blood pressure
3.3K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.3K
Disturbances in Heart Rhythm
1.0K
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
1.0K
Anticoagulant Drugs: Low-Molecular-Weight Heparins
747
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
747


