对ICU痴呆症和相关炎症标志物的抗精神病使用
Heather Torbic1, Alyssa Chen1, Mollie Lumpkin1
1Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
Journal of intensive care medicine
|September 19, 2023
概括
在患有狂妄症的重症患者中,IL-6和IL-8等炎症标志物是可变的. 在这项研究中,使用抗精神病药物并没有改善妄或减少炎症.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- Delirium 在重症患者中很常见.
- 炎症性细胞因子可能在狂妄病的发病过程中发挥作用.
- 抗精神病药物在控制妄和炎症方面的疗效尚不清楚.
研究的目的:
- 为了评估发炎性细胞因子 (IL-6,IL-8) 在 Delirium 的危急病患者的生产.
- 评估细胞因子水平,痴呆症进展和抗精神病药物使用之间的关系.
- 识别与不同炎症概况和结果相关的患者特征.
主要方法:
- 对患有痴呆症的成年重症患者进行前性观察队列研究 (CAM-ICU得分为正).
- 在24小时内趋势介质素-6 (IL-6) 和介质素-8 (IL-8) 水平.
- 根据年龄,疾病严重程度 (APACHE III),机械通风和感染,分析患者群,比较抗精神病药物暴露和炎症标志物.
主要成果:
- 根据抗精神病药物暴露,IL-6和IL-8水平没有显著差异.
- 确定了两个患有不同炎症状况和基线细胞因子水平的患者群.
- 1组患者,具有更多的共炎性疾病,在数值上较低的IL-6/IL-8和更多的无狂妄日 (17.0对6.0).
结论:
- Delirium 的危急病患者的 互乐金-6 和 互乐金-8 水平是可变的.
- 服用抗精神病药物并没有改善妄的结果或减少炎症标志物.
- 患者聚类表明,不同的炎症特征可能会影响危急疾病中的妄想持续时间.
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