诺基诺与大动脉动脉瘤或解剖之间缺乏关联
Kyungmin Huh1, Minsun Kang2, Jaehun Jung2,3
1Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea.
European heart journal
|September 19, 2023
概括
这项研究发现,在使用化 (FQ) 和第三代化 (3GC) 之间,大动脉动脉瘤和剖析 (AA/AD) 的风险没有显著差异. 临床医生可以在有必要时自信地开处方FQ,因为它们不会增加AA/AD风险.
科学领域:
- 药物监督 药物监督 药物监督
- 心血管流行病学心血管流行病学
- 传染病管理 传染病管理
背景情况:
- 以前的报道表明,在使用诺基诺 (FQ) 时,大动脉动脉瘤和剖析 (AA/AD) 的风险增加.
- 根据指示提出了混因素,需要对FQ-AA/AD关联进行进一步调查.
研究的目的:
- 调查与口服诺 (FQ) 使用相关的AA/AD风险.
- 为了比较AA/AD的风险在FQ和第三代脑素 (3GC) 用户之间.
主要方法:
- 全国范围的基于人口的研究 (2005-2016),使用国家医疗保险服务数据库对20岁以上的成年人进行研究.
- 主要结局:住院或在医院死亡与AA/AD诊断.
- 分析方法包括自我控制的病例系列和治疗加权的Cox比例危险模型的逆概率.
主要成果:
- 包括954,308名患者 (777,109名FQ用户,177,199名3GC用户).
- 在风险时期,AA/AD的发病率比率在3GC组比FQ组更高.
- 在FQ和3GC使用者之间,AA/AD风险没有显著差异 (aHR 0.752;95%CI 0.515-1.100).
结论:
- 与第三代化素 (3GC) 相比,口服化 (FQ) 的使用与大动脉动脉瘤和解剖 (AA / AD) 的风险显著增加无关.
- 这些发现支持在临床上适用的情况下继续使用FQ,而不必过分担心AA/AD风险.
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