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与代谢综合征相关的认知障碍与白质过强度和功能网络分析

Wenhui Zheng¹, Xia Zhou¹, Jiabin Yin¹

¹Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, China.

Obesity (Silver Spring, Md.)

|September 19, 2023

概括

白质超强度 (WMHs) 在代谢综合征 (MetS) 中介于认知障碍. 减少大脑网络效率是关键因素,影响注意力,语言和整体认知功能.

科学领域:

神经成像是一种神经成像.
神经学神经学
代谢障碍代谢障碍代谢障碍

背景情况:

代谢综合征 (MetS) 与认知能力下降有关.
白质超强度 (WMHs) 在MetS中很常见,可能会影响大脑功能.

研究的目的:

调查 WMHs 与 MetS 认知障碍之间的关系.
探索这种关联背后的神经网络机制.

主要方法:

与MetS-WMH,MetS-no WMH和对照组进行横截面研究.
休息状态fMRI和图形理论分析来评估大脑网络的效率.
调解分析以确定WMHs在认知障碍中的作用.

主要成果:

MetS-WMH组显示全球,本地和节点网络效率降低,特别是在突出网络中.
功能网络效率与认知表现有显著的相关性.
WMHs调解了MetS与注意力,语言和全球功能认知下降之间的关系.

结论:

WMH在MetS和认知障碍之间的关联中起着调解作用.
功能性大脑网络效率下降可能是神经机制.

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