肠心血管连接:心血管治疗的新时代
Chak Kwong Cheng1,2, Yu Huang1,2
1School of Biomedical Sciences and Li Ka Shing Institute of Health Science; The Chinese University of Hong Kong, Hong Kong SAR 999077, China.
Medical review (2021)
|September 19, 2023
概括
肠道微生物群,一个复杂的微生物生态系统,越来越多地被认为对心血管健康的作用. 肠道微生物组的失衡可能导致炎症和心血管疾病,突出潜在的治疗点.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物组包括数万亿个微生物,与宿主相互作用,作为一个动态的器官系统.
- 越来越多的证据将肠道微生物组失调与免疫系统失调和心血管平衡破坏联系在一起.
- 肠道微生物组的变化和肠道透性都与心血管疾病的病理生理学有关.
研究的目的:
- 探索肠道微生物组与心血管健康之间的复杂关系.
- 阐明肠道衍生因素影响心血管功能的机制.
- 确定器官间轴 (如肠血管,心肠) 在心血管风险中的作用.
主要方法:
- 关于肠道微生物组和心血管疾病的当前科学文献的综述.
- 对将肠道微生物代谢物与宿主生理联系起来的分子和细胞机制的分析.
- 检查有关肠道相关轴的受损交叉语音的证据.
主要成果:
- 来自肠道的代谢物,毒素和会导致炎症和心血管功能障碍.
- 特定的微生物形状和增加的肠道透性与心血管疾病有关.
- 沿着肠-器官轴的通信中断与心血管风险升高有关.
结论:
- 肠道微生物组在维持心血管平衡方面发挥着至关重要的作用.
- 针对肠道微生物组的治疗策略可能为心血管和代谢疾病提供新的方法.
- 恢复健康的肠道微生物组是预防和治疗疾病的一个有希望的途径.
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