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在伊朗宫癌患者中 lncRNA CYTOR 的表达水平

Ali Rajabi¹, Narges Dastmalchi¹, Neda Shokri¹

¹Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Reports of biochemistry & molecular biology

|September 19, 2023

概括

细胞核长非编码RNA (lncRNA) 在宫癌组织中显著上调. 这一发现表明CYTOR可能作为宫癌的潜在诊断生物标志物,有助于诊断和治疗.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

长非编码RNAs (lncRNAs) 在癌症发病和发展中发挥着关键作用.
lncRNAs被认为是癌症诊断和治疗的潜在生物标志物.
这项研究研究了在人类宫癌中CYTOR lncRNA的表达.

研究的目的:

为了检查宫癌组织中CYTOR lncRNA的表达水平,与相邻的健康组织相比.
评估CYTOR作为宫癌诊断生物标志物的潜力.
评估CYTOR表达与宫癌的临床病理特征之间的关联.

主要方法:

使用定量实时PCR (qRT-PCR) 来测量CYTOR lncRNA的表达.
分析了115对瘤和相邻的健康宫组织样本.
生物标志物的活性是使用接收器操作特征 (ROC) 曲线分析来评估的.

主要成果:

与非癌症样本相比,宫癌样本中细胞细胞表达显著增加 (P<0.0001).
在CYTOR表达和宫癌状亚型之间发现了显著的相关性 (p=0.046).
在ROC曲线下的面积 (AUC) 为0.88,敏感度为81.74%,特异性为80%,表明潜在的生物标志物实用性.

结论:

在人类宫癌组织中,细胞细胞因子过度表达.
在宫癌中,CYTOR可能起到瘤基因的作用.
作为宫癌诊断和可能治疗的潜在生物标志物,CYTOR显示出希望.

关键词:

生物标志物生物标志物半体半体半体半体宫癌是发生在宫癌的原因之一.在 lncRNA 中,qRT-PCR 是一个很好的方法.

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