肥胖和非酒精性脂肪性肝病患者的心脏结构和功能
Zemfira Asatullina1, Albina V Sineglazova1
1Primary Care and General Practice, Kazan State Medical University, Kazan, RUS.
Cureus
|September 19, 2023
概括
非酒精性脂肪性肝病 (NAFLD) 与心脏变化有关,即使没有糖尿病或心脏病. 这项研究发现NAFLD影响心脏结构和功能,表明需要综合患者评估和预防策略.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢综合征研究 代谢综合征研究
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的全球健康问题,与肥胖和2型糖尿病 (T2DM) 越来越相关.
- 与肥胖和代谢综合征分开,NAFLD对心脏健康的独立影响需要进一步调查.
- 了解这些关联对于管理与NAFLD相关的心脏代谢风险至关重要.
研究的目的:
- 研究NAFLD对肥胖个体心脏结构和功能的影响.
- 为了确定NAFLD是否与心脏变化独立相关,调整身体质量指数 (BMI) 和腹部肥胖 (AO).
- 探索肝硬化/纤维化指数与心脏参数之间的相关性.
主要方法:
- 一项涉及164名参与者的横截面研究,根据BMI,AO和NAFLD状态分为四组.
- 综合性评估包括临床检查,生物化学分析,心声学和使用控制衰减参数 (CAP) 和肝硬度测量 (LSM) 的肝脏评估.
- 进行了统计分析,以比较群体并确定独立的协会,并对共变量进行调整.
主要成果:
- 患有NAFLD的个体表现出心脏结构和功能的显著变化,包括左心房 (LA) 体积增加,室间隔膜 (IVS) 厚度和左心室 (LV) 心肌质量.
- 在NAFLD患者中观察到LV射出分数和LV中风体积指数的下降.
- 肝硬化指数 (HSI),CAP分数和LSM值显示与各种心脏参数的相关性,例如LA体积和LV心肌质量.
结论:
- 即使没有先前存在的心血管疾病或糖尿病,NAFLD的存在也与心脏结构和功能的不良变化有关.
- 这些发现强调了在NAFLD患者中考虑心脏健康的重要性.
- 该研究支持在NAFLD人群中开发心力衰竭的综合评估和预防策略,以保持排泄分数.
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