CDKN2B-AS1基因多态和习惯性风险因素对口腔癌的相互作用影响
Jung-Chun Yeh1,2, Yi-Tzu Chen1,2, Ying-Erh Chou3,4
1School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
Journal of cellular and molecular medicine
|September 19, 2023
概括
CDKN2B-AS1中的单核酸多态性不会影响口腔癌的风险,但rs1333048与吸烟者和白使用者的晚期瘤阶段有关.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种具有复杂原因的致命癌症.
- 像CDKN2B-AS1这样的长非编码RNA在癌症发育中起作用.
- 研究CDKN2B-AS1的遗传变异可能会揭示对OSCC易感性的新见解.
研究的目的:
- 检查CDKN2B-AS1中的特定单核酸多态 (SNPs) 与发展OSCC的风险之间的关联.
- 探索CDKN2B-AS1 SNPs与OSCC患者的临床特征之间的相关性.
- 确定遗传变异是否与OSCC进展中的环境风险因素相互作用.
主要方法:
- 在1060个OSCC病例和1183个对照中对5个CDKN2B-AS1SNP (rs564398,rs1333048,rs1537373,rs2151280,rs8181047) 的基因定型.
- 统计分析以比较病例和对照之间的SNP频率.
- 基于临床参数和习惯性风险因素 (,吸烟) 的分层分析.
主要成果:
- 在五个研究的CDKN2B-AS1SNP和OSCC的整体风险之间没有发现显著的关联.
- rs1333048 SNP与晚期 (III/IV) 和大尺寸 (>2厘米) 瘤有显著的关联.
- 这种关联在经常贝特尔或吸烟的人群中突出,这表明了相互作用效应.
结论:
- CDKN2B-AS1 SNPs似乎没有影响对OSCC的敏感性.
- 在CDKN2B-AS1的rs1333048多态可能有助于口腔癌的进展,特别是在具有特定行为风险因素的个体.
- 这些发现突出了在先进OSCC的发展中潜在的基因环境相互作用.
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