过高甘油酸性急性胰腺炎的凝血指数和D-二次数水平的变化及其在预测疾病严重程度方面的价值
Yuanyuan Gou1, Long Yao2, Jie Cao3
1Department of Gastroenterology, Jiangjin Hospital Affiliated to Chongqing University (Jiangjin District Central Hospital of Chongqing), Chongqing 402260. 1552735871@qq.com.
概括
过高甘油三性急性胰腺炎 (HTG-AP) 涉及凝血系统功能障碍. 升高的前列血时间 (PT) 和D-二次体水平是严重的HTG-AP的独立风险因素,有助于早期预测.
科学领域:
- 凝血和纤维化解的过程
- 消化系统疾病 消化系统疾病
- 生物标志物发现发现
背景情况:
- 过高甘油三性急性胰腺炎 (HTG-AP) 是一种严重的消化系统疾病,发病率越来越高.
- 凝血和纤维溶解系统的功能障碍在HTG-AP的发展中起着至关重要的作用.
- 早期识别严重病例对于改善预后至关重要.
研究的目的:
- 为了研究HTG-AP患者的凝血参数变化.
- 评估凝血参数和D-二次体在预测HTG-AP严重性的价值.
- 为了确定严重的HTG-AP的独立风险因素.
主要方法:
- 对189名HTG-AP患者进行了回顾性分析.
- 在轻度和重度组之间的凝血指数 (PT,APTT,FIB),D-二次体,CRP和APACHE II分数的比较.
- 使用斯皮尔曼的相关性分析.
- 逻辑回归和ROC曲线分析用于预测价值.
主要成果:
- 严重的HTG-AP组显示出明显更高的PT,FIB和D-二元水平 (P<0.001).
- 提升的PT和D-二次体被确定为严重HTG-AP的独立风险因素 (P<0.05).
- 结合PT和D-二次体显示了HTG-AP严重性的高预测值 (AUC=0.797).
结论:
- 在早期的HTG-AP中,凝血和纤维溶解系统异常.
- PT,FIB和D-二次体水平与HTG-AP严重程度有积极的相关性.
- 升高的PT和D-二次体是严重HTG-AP的有价值的早期预测因素.
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