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使用生物相容的共价有机框架 (COFs) 进行药物递送,以实现治疗方法

Pritam Ghosh¹, Priyabrata Banerjee^2,3

¹Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai Campus, Chennai 600127, Tamilnadu, India. ppritamghosh@gmail.com.

Chemical communications (Cambridge, England)

|September 19, 2023

概括

联有机框架 (COF) 为药物输送提供了多功能平台,使治疗分子在生物环境中能够有效封装和受控释放. 本次审查强调了它们在先进的生物医学应用中的潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

联有机框架 (COF) 是由有机构建块构建的先进材料,具有可调节的特性和坚固的结构.
由于它们的轻量化性质,易于合成和适应性特性,使得COF可用于各种应用,特别是生物医学领域.
正在探索COF的治疗作用,包括药物输送和联合光动力-光热 (PDT-PTT) 疗法.

研究的目的:

本综述全面审查了COF在药物输送系统中的应用.
它侧重于COF支架内的药物封装和解封的机制.
该研究强调了COF在生物介质 (包括活细胞) 中传递治疗剂的有效性.

主要方法:

对最近的科学文献进行了彻底的审查.
分析了专注于COF合成,药物加载和体外/体外药物释放研究的出版物.
该审查综合了各种COF架构及其在药物输送中的性能信息.

主要成果:

COFs显示出大量的潜力,可以封装各种各样的药物分子.
从COF载体中控制释放 (解封) 药物已经在各种生物环境中成功实现.
研究表明,在体外和体外模型中,使用多功能COF支架进行有效的药物递送.

结论:

药物输送器是先进药物输送系统的高度适应性和有效平台.
它们封装和释放药物的能力可控地将它们定位为未来生物医学疗法的关键材料.
对基于COF的药物输送的进一步研究有望在有针对性和高效的治疗干预中取得重大进展.

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