维生素K与T2DM之间的关系:系统性审查和元分析
Boyang Qu1, Shoumeng Yan2, Yanrong Ao1
1Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Changchun, China. cuiweiwei@jlu.edu.cn.
Food & function
|September 19, 2023
概括
补充维生素K有效降低禁食血糖和胰岛素抵抗. 这一元分析还显示,服用维生素K可以降低2型糖尿病的风险.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 维生素K在预防疾病中的作用是公认的,但其对血糖调节的影响仍在争论中.
- 以前的研究表明,维生素K对血糖控制和2型糖尿病 (T2DM) 风险的影响有潜在的益处,但缺乏确的证据.
研究的目的:
- 为了评估维生素K补充剂对关键血糖指标的影响:禁食血糖 (FBS),禁食胰岛素 (FINS) 和胰岛素抵抗的恒温模型评估 (HOMA-IR).
- 调查维生素K摄入量与患2型糖尿病 (T2DM) 的风险之间的关联.
主要方法:
- 进行了一项全面的元分析,搜索主要数据库 (Cochrane,PubMed,科学网,Medline,EMBASE) 到2023年4月.
- 包括七项研究 (813名参与者) 用于血糖指标和五项研究 (105,798名参与者) 用于T2DM风险评估.
主要成果:
- 维生素K补充剂显著降低了FBS (SMD = -0.150) 和HOMA-IR (SMD = -0.200),但没有显著影响FINS.
- 在维生素K摄入量和T2DM风险降低之间发现了显著的关联 (HR = 0.79).
结论:
- 维生素K补充剂在调节FBS和HOMA-IR方面发挥着重要作用.
- 摄入维生素K与患T2DM风险降低有关.
- 进一步的大规模临床试验是有必要的,以确认这些发现,并探索潜在的机制.
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