在性急性损伤中的益生菌,双盲,随机对照试验
Jonathan S Chávez-Íñiguez1,2, Miguel Ibarra-Estrada3, Alejandro Martínez Gallardo-González1,2
1Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
Renal failure
|September 19, 2023
概括
益生菌在败血症相关的急性损伤 (AKI) 中没有改善功能恢复. 虽然它们是安全的,但它们并没有降低死亡率或减少对置换治疗的需求.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 败血症引起的急性损伤 (AKI) 与肠道失生症有关.
- 失生症对功能恢复 (KFR) 有负面影响.
- 益生菌可能会恢复肠道微生物群的平衡,并改善KFR.
研究的目的:
- 为了评估益生菌对KFR在AKI由于败血症的患者的影响.
- 评估益生菌对死亡率,脏替代疗法 (KRT),尿素水平,尿液量,血清电解质和不良事件的影响.
主要方法:
- 一个双盲,随机的临床试验比较益生菌和安慰剂.
- 92名患有败血症相关的AKI患者被随机分配 (1:1) 接受益生菌或安慰剂7天.
- 评估的结果包括KFR,死亡率,KRT,尿素,尿液量,电解质和第7天的不良事件.
主要成果:
- 与安慰剂相比,益生菌没有显著改善KFR (HR 0.93,p=0.81).
- 在6个月死亡率方面没有观察到显著的益处 (p=0.06).
- 益生菌组显示尿素水平显著降低 (p=0.04),与安慰剂组不同. 其他结果在各组之间是相似的.
结论:
- 七天的益生菌管理没有提高KFR在败血症相关的AKI.
- 发现益生菌是安全的,但没有改善其他临床结果,如死亡率或KRT需要.
- 可能需要进一步的研究来探索不同的益生菌菌株或持续时间.
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