血D-二分体作为IgA脏病进展的潜在预测因素:一个队列研究
Guizhen Yu1, Yan Jiang1, Zishu Xu2
1Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University; Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province; National Key Clinical Department of Kidney Diseases; Institute of Nephrology, Zhejiang University; the Third Grade Laboratory under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China.
Renal failure
|September 19, 2023
概括
血D-二聚合物水平升高表明凝血激活,并与IgA脏病 (IgAN) 中脏病恶化有关. 在Igan患者中,较高的D-二聚物水平显著增加了病进展的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 血液学 血液学 血液学
- 内部医学 内部医学
背景情况:
- 凝血障碍与慢性病 (CKD) 的进展有关.
- 血D-二聚体水平反映了凝血系统的激活,但它们在IgA瘤病变 (IgAN) 严重程度和进展中的作用尚不清楚.
研究的目的:
- 调查血D-二聚物水平与IgA脏病患者病进展风险之间的关联.
主要方法:
- 评估了1818名IGAN患者的队列,在脏活检中测量了血D-二聚物水平.
- 病的进展被定义为估计的膜过率 (eGFR) 或末期病 (ESKD) 的50%下降.
- 限制立方线和Cox比例危险模型被用于分析D-二次元水平和进展事件之间的关联.
主要成果:
- 与健康对照组相比,IgAN患者的血D-二聚体水平较高,并且与蛋白尿和血清银河糖缺乏IgA1积极相关.
- D-二聚合物水平与eGFR和牛津T和C分数负相关.
- 较高的血D-二聚合物水平与病进展事件的风险增加显著相关,即使在调整了临床和病理因素后.
结论:
- 血D-二聚合物水平升高是IgA脏病发作中脏疾病进展的重要危险因素.
- 血D-二分体可以作为一种有价值的生物标志物,用于预测IgAN中的疾病严重程度和结果.
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