在高海拔地区的藏人中,血红蛋白度与高血压风险之间的关联
Xueting Liu1, Changqiang Yang1, Xin Zhang1
1Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.
Journal of clinical hypertension (Greenwich, Conn.)
|September 19, 2023
概括
高血红蛋白水平增加了居住在高海拔地区的藏人血压高的风险. 这项研究发现,大约176g/L以上的血红蛋白度显著提高患高血压的几率.
科学领域:
- 高海拔的生理学 高海拔的生理学
- 心血管健康的心血管健康
- 血液学 血液学 血液学
背景情况:
- 关于血红蛋白度和高血压之间的联系存在不一致的发现.
- 有限的研究解决了这种关系在高海拔土著人口,如西藏人.
- 高海拔带来独特的生理挑战,可能会影响血红蛋白水平和高血压风险.
研究的目的:
- 研究居住在高海拔地区的藏人血红蛋白度与高血压风险之间的关联.
- 确定血红蛋白水平升高,包括与高海拔多细胞血症相关的血红蛋白水平,是否会导致该人口的高血压.
主要方法:
- 在卢湖县 (平均海拔3500米) 的1547名藏人中进行了横截面研究.
- 用多变量二元逻辑回归和平滑曲线拟合来分析这种关系.
- 在高血压和非高血压个体之间测量和比较血红蛋白度.
主要成果:
- 与正常血压 (157.7 ± 19.2 g/L) 相比,高血压的藏人血红蛋白度显著更高 (165.9 ± 21.5 g/L).
- 在调整后,血红蛋白度增加1g/L与高血压风险增加有关 (OR1.02;95% CI1.01-1.02).
- 血红蛋白水平超过173 g/L (OR 2.39) 和176 g/L (OR 1.04) 与显著更高的高血压风险有关.
- 高海拔多细胞血症 (OR 2.92) 和轻度多细胞血症 (OR 1.74) 也与高血压风险增加有显著联系.
结论:
- 血红蛋白度与高血压风险显著相关,在高海拔地区的藏人中.
- 血红蛋白水平升高,特别是超过176g/L,与高血压风险大幅增加有关.
- 高海拔多细胞血是导致高血压的关键因素.
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