干扰素α对COVID-19住院死亡率的影响:一项大规模的倾向性得分匹配研究
Mohamad Amin Pourhoseingholi1, Amirreza Rafiei Javazm1, Naghmeh Asadimanesh2
1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
European cytokine network
|September 19, 2023
概括
干扰素α (IFN-α) 治疗,单独或与雷梅西维尔一起,对住院患者的COVID-19死亡率或ICU入院没有显著影响. 需要进一步的研究来探索IFN-α在COVID-19中的潜在治疗作用.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 关键护理医学 关键护理医学
背景情况:
- 冠状病毒感染可以引发细胞因子风暴,导致ARDS和死亡率.
- 干扰子 (IFN) 是重要的免疫调节剂,需要对它们在COVID-19中的作用进行调查.
- 这项研究评估了IFN-α在住院COVID-19患者的疗效,包括或不包括remdesivir.
研究的目的:
- 研究IFN-α单独或与雷梅西维尔结合对COVID-19患者结局的影响.
- 分析接受IFN-α治疗的患者的死亡率和ICU入院率.
主要方法:
- 一项多中心的回顾性研究包括3764名符合条件的COVID-19患者.
- 倾向分数匹配 (PSM) 用于创建 851 个接受 IFN-α 和 851 个对照患者的平衡组.
- 分析了IFN-α对COVID-19结果的未调整和调整后的影响.
主要成果:
- 在PSM分析中,IFN-α和对照组之间的生存曲线没有显著差异 (p=0.340).
- 未经调整的分析显示,IFN-α的死亡风险在统计学上显著降低 (p=0.043,HR:0.86).
- 结合IFN-α和雷梅西维尔的联合治疗没有显著的益处 (HR:0.89).
结论:
- 用remdesivir或不用remdesivir进行皮下注射的IFN-α并没有显著影响COVID-19死亡率或ICU入院.
- 建议进行进一步的临床试验,以探索IFN-α的最佳时间,亚型和管理,以寻找COVID-19中潜在的治疗益处.
更多相关视频
相关概念视频
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Bias in Epidemiological Studies
343
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
343
Confounding in Epidemiological Studies
188
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
188
Controls in Experiments
7.8K
When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
7.8K


