乳腺癌相关淋巴的危险因素:一个总体审查
Aomei Shen1,2,3, Wanmin Qiang1, Liyuan Zhang1
1Department of Nursing, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Annals of surgical oncology
|September 19, 2023
概括
识别乳腺癌相关淋巴结胀 (BCRL) 的危险因素对于预防至关重要. 这次审查发现先天的个人特征,如更高的BMI与BCRL有关,但证据质量较低,需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 淋巴 edem 研究 研究 淋巴 edem 研究
- 证据综合 证据综合
背景情况:
- 与乳腺癌相关的淋巴 (BCRL) 是幸存者的一个重大问题.
- 之前的系统审查已经探讨了BCRL的风险因素.
- 需要对现有证据进行全面的识别和质量评估.
研究的目的:
- 系统地确定BCRL的潜在风险因素.
- 评估BCRL风险因素现有系统审查和元分析的方法质量和证据质量.
主要方法:
- 在多个数据库 (PubMed,Embase,CINAHL等) 中进行系统搜索. 在2022年11月之前.
- 使用AMSTAR2,ROBIS和GRADE进行独立研究选,数据提取和质量评估.
- 评估研究重叠,小研究效应和异质性 (I2,埃格尔的P值).
主要成果:
- 包括 14 篇出版物 (10 篇元分析,4 篇系统性评论) 确定了 39 个因素.
- 13个与人格特征相关的先天性因素,包括更高的体重指数和下淋巴结剖析,与BCRL有显著的关联.
- 乳房重建作为一种保护因素而出现.
- 方法质量主要是低或非常低,大多数评论中存在偏差的高风险.
结论:
- 目前已确定的BCRL风险因素主要是先天的个人特征.
- 低的方法和证据质量需要谨慎.
- 未来的研究应该专注于精心设计的研究和强大的元分析,以探索行为,人际关系,环境,遗传和病理生理因素.
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