系统性免疫炎症指数和阻塞性睡眠呼吸暂停之间的关系
Zahide Yılmaz Güneş1, Filiz Manga Günaydın2
1Neurology Clinic, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey. yilmazzahide@hotmail.com.
Sleep & breathing = Schlaf & Atmung
|September 19, 2023
概括
系统性免疫炎症指数 (SII) 是预测阻塞性睡眠呼吸暂停 (OSA) 的潜在新生物标志物. 在OSA患者中观察到较高的SII和中性粒细胞与淋巴细胞比率 (NLR),与较低的氧和相关.
科学领域:
- 医学研究 医学研究
- 生物标志物发现发现
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,对健康有重大影响.
- 确定可靠的生物标志物用于OSA诊断和预测对于及时干预至关重要.
研究的目的:
- 评估在被诊断患有阻塞性睡眠呼吸暂停 (OSA) 的患者中系统性免疫炎症指数 (SII) 的预测值.
主要方法:
- 在OSA患者和对照组之间比较血液学指数,包括SII,中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR) 和单细胞与淋巴细胞比率 (MLR).
- 在OSA患者中分析了这些指数和多睡眠学 (PSG) 参数之间的相关性.
主要成果:
- 与对照组相比,患有OSA的患者表现出明显更高的SII和NLR值.
- 在SII和NLR之间发现了显著的负相关性,睡眠期间氧和水平最低.
- 确定SII (290) 和NLR (1.71) 的切割值,用于潜在的OSA预测.
结论:
- 系统性免疫炎症指数 (SII) 显示出作为预测阻塞性睡眠呼吸暂停的新型,可访问的生物标志物的潜力.
- SII和NLR可以作为与OSA严重程度相关的快速,经济有效的指标,特别是关于夜间氧气脱的指标.
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