月经前障碍,更年期的时间,以及血管运动症状的严重程度
Yihui Yang1, Unnur A Valdimarsdóttir1,2,3, JoAnn E Manson2,4,5
1Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
患有月经前障碍 (PMD) 的女性面临更早更年期和严重血管运动症状 (VMS) 的更高风险. 这些发现表明,PMD可能预示着未来更年期的时间和症状的严重程度.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇女健康 妇女健康
- 流行病学 流行病学
背景情况:
- 月经前障碍 (PMD) 在更年期停止,但它们与更年期时间和症状严重程度的关联仍然不清楚.
- 了解这种联系对于识别早期更年期和相关健康问题风险的妇女至关重要.
研究的目的:
- 为了前性地调查月经前期障碍 (PMD) 与早期更年期风险之间的联系.
- 检查PMD和与更年期相关的血管运动症状 (VMS) 的严重程度之间的关系.
主要方法:
- 基于人口的队列研究,使用护士健康研究II (1991-2017) 的数据.
- 经过自我报告和症状调查问卷识别的月经前障碍 (PMDs).
- 考克斯的比例危险模型和逻辑回归分析了PMD,早期更年期和VMS之间的关联.
主要成果:
- 患有PMD的女性具有显著增加的早期自然更年期风险 (调整后的危险比率,2.67).
- 诊断PMD与中度或重度血管运动症状 (VMS) 的可能性更高 (调整后的几率比,1.68).
- 在PMD和轻度VMS之间没有发现任何关联.
结论:
- 月经前障碍 (PMD) 与早期更年期和中度至严重的血管运动症状 (VMS) 的风险增加有关.
- PMDs可以作为影响更年期时间和症状严重性的生理因素的指标.
- 识别患有PMD的妇女可以为那些处于更早更年期和随后的健康问题风险的妇女提供早期干预.
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