转移性前列腺癌患者系统治疗的时间趋势:一项国家队列研究
Anne Holck Storås1,2, Kaitlyn Tsuruda1, Sophie Dorothea Fosså1,2,3
1Department of Research, Cancer Registry of Norway, Oslo, Norway.
Acta oncologica (Stockholm, Sweden)
|September 19, 2023
概括
从2010年到2018年,转移性前列腺癌 (mPCa) 的全身治疗增加了,在2015年之后,对于荷尔蒙敏感病例,多西的使用显著增加. 然而,只有不到一半的患者接受了这些先进疗法.
科学领域:
- 在瘤学瘤学.
- 临床药房 临床药房
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在2010-2018年期间,转移性前列腺癌 (mPCa) 的新系统治疗方法出现.
- 有限的数据存在于这些疗法超出雄激素剥夺疗法 (ADT) 的现实世界的采用.
- 这项研究调查了挪威mPCa患者的治疗模式.
研究的目的:
- 描述接受全身治疗mPCa.患者的特征.
- 分析随着时间的推移系统治疗使用的趋势.
- 评估Docetaxel引入后对激素敏感mPCa (mHSPC) 的治疗转换.
主要方法:
- 一项国家队列研究包括了2770名在2010-2018年间诊断的mPCa患者.
- 系统性治疗数据 (多西塔克塞尔,阿比拉,恩扎胺,卡巴西塔克塞尔,-223) 来自挪威卫生登记处.
- 描述性统计分析了患者和疾病特征.
主要成果:
- 48%的mPCa患者接受了超出ADT的全身治疗.
- 在研究期间,系统性治疗使用量增加.
- 治疗模式在2015年后发生了转变,mHSPC患者使用多西素的比例增加 (48%对比4%).
结论:
- 在mPCa患者的系统治疗使用在2010-2018年间增加,但仍低于50%.
- 在2015年之后,mHSPC的多西素采用量显著增加,与指南保持一致.
- 对没有接受全身治疗的患者进行进一步研究是必要的.
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