怀孕中再次流产的妇女中的铁血球蛋白抗体:系统性审查和元分析
Perrine Huisman1,2,3, Jesper Krogh1,2, Claus Henrik Nielsen4,5
1Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Thyroid : official journal of the American Thyroid Association
|September 19, 2023
概括
甲状腺自身免疫,特别是甲状腺蛋白抗体 (TgAbs),在重复流产 (RPL) 的妇女中更为常见. 这表明TgAbs和生殖挑战之间存在重要联系,强调需要提高认识.
科学领域:
- 生殖内分泌学和免疫学
- 自免疫性疾病 自免疫性疾病
- 妇女健康 妇女健康
背景情况:
- 甲状腺自身免疫性是生殖年龄妇女普遍存在的疾病.
- 复发性流产 (RPL) 影响了许多夫妇,通常是由于未确定的原因.
- 现有的研究主要集中在甲状腺过氧化酶抗体 (TPOAbs),忽视了甲状腺球蛋白抗体 (TgAbs).
研究的目的:
- 系统地评估发生重复流产 (RPL) 的妇女中铁血球蛋白抗体 (TgAbs) 的患病率.
- 为了确定TgAb阳性是否与后续怀孕的结果有关.
- 调查TgAbs在RPL中的作用,超出TPOAbs.
主要方法:
- 在PubMed和Embase上进行了系统的文献搜索,截至2023年4月29日.
- 包括报道了RPL妇女TgAbs的研究.
- 使用随机效应模型的元分析被用来计算带有置信区间 (CI) 的聚合赔率比率 (ORs).
主要成果:
- 这项研究包括28项研究,其中包括6868名女性的数据.
- 与对照组相比,患有RPL (OR = 1.93;CI 1.27-2.92) 的女性的TgAb阳性显著更高.
- 结合TgAbs和/或TPOAbs也显示出与RPL的显著关联 (OR = 2.66;CI 1.75-4.05).
结论:
- 重复流产的妇女表现出显著更高的甲状腺蛋白抗体 (TgAbs) 的流行率.
- 这些发现强调了在评估RPL时考虑甲状腺自身免疫,特别是TgAbs的重要性.
- 需要进一步的研究来澄清TgAb阳性对妊娠结果的潜在影响,因为研究异质性.
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