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XEN 45凝支架植入在开放角度的玻璃眼:一个前性研究的5年结果
Julien Torbey1, Archibald Paillard1, Harsha L Rao2
1Glaucoma Research Centre, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland.
Journal of glaucoma
|September 19, 2023
概括
在XEN 45凝支架是安全和有效的开角玻璃眼,显著降低眼内压力和药物需要超过五年. 早期的成功预测了长期的结果,而针刺可能会增加失败的风险.
科学领域:
- 眼科医生 眼科 眼科
- 手术创新 在外科创新.
- 视光眼管理 视光眼管理
背景情况:
- 开角光眼 (OAG) 对保持目标眼内压力 (IOP) 构成重大挑战.
- 医疗管理往往被证明是不够的,需要手术干预.
- 该XEN 45凝支架提供了一个最小的侵入性选择,以减少IOP.
研究的目的:
- 评估XEN 45凝支架植入OAG患者的5年临床结果.
- 在现实临床环境中评估XEN 45凝支架的安全性和有效性.
- 为了确定长期外科成功的预测因素.
主要方法:
- 一项前性,单中心的干预性研究,涉及170只眼睛 (126名患者) 患有不受控制的IOP.
- XEN 45凝支架植入,作为单独的手术或与化相结合进行.
- 在60个月内评估完整和合格的外科成功,平均内血压,药物使用和重新手术率.
主要成果:
- 平均内血压从基线 (19.8 mmHg) 降低了37.0%至5年后12.6 mmHg (P < 0.001).
- 眼部低血压药物的使用量从基线 (2.0种药物) 降低了60%至5年后的0.8种药物 (P < 0.001).
- 3年后的完全成功是5年成功的强有力的预测因素 (OR: 3.06),而针与更高的失败率有关 (OR: 3.6).
结论:
- 在OAG患者中,XEN 45凝支架植入是一种安全有效的程序,可以在5年内实现临床上有意义的IOP和药物减少.
- 3年后的手术成功是5年后持续疗效的重要预测因素.
- 术后针刺的需要与手术失败率的增加有关.
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