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在加拿大阿尔伯塔省儿童中评估脂质评估的流行情况
Susan Christian1, Ross Ridsdale2, Mu Lin2
1Department of Medical Genetics (Christian, Risdale) and Department of Pediatrics (Khoury), University of Alberta; Alberta SPOR Support Unit and Provincial Research Data Services (Lin), Alberta Health Services, Edmonton, Alta. smc12@ualberta.ca.
CMAJ open
|September 19, 2023
概括
阿尔伯塔省的儿科脂质评估很少发生,只有4.3%的幼儿和19.9%的老年儿童接受查. 早期诊断家族性高胆固醇血症对于降低心血管风险至关重要.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 公共卫生 公共卫生
- 遗传学 遗传学 是一个
背景情况:
- 家族性高胆固醇血症 (FH) 是一种常见的,遗传性疾病,导致高LDL-C和心血管疾病风险增加.
- 早期儿童治疗显著降低了与FH相关的长期健康风险.
- 评估阿尔伯塔省的儿科脂质评估患病率对于公共卫生倡议至关重要.
研究的目的:
- 为了确定阿尔伯塔省儿科脂质评估的流行率.
- 分析脂质评估频率的趋势随着时间的推移.
- 为了确定脂质评估率的人口差异.
主要方法:
- 来自阿尔伯塔卫生 (2012-2021) 的实验室和行政数据的回顾性审查.
- 对两个儿科队列 (2-10岁和9-17岁) 进行纵向评估的分析.
- 对所有儿童 (2013-2021) 年度脂质评估频率的检查.
主要成果:
- 脂质评估在4.3%的2-10岁儿童和19.9%的9-17岁儿童中进行.
- 女孩和农村社区的孩子不太可能接受脂质评估.
- 可能的FH (LDL-C ≥4.0 mmol/L) 在1.1-1.2%的评估儿童中被确定;对16名儿童开处方他类药物治疗.
结论:
- 阿尔伯塔省的儿科脂质评估率低于最佳水平.
- 需要提高人们对FH益处的认识,克服诊断障碍.
- 早期的FH诊断和治疗对于长期的儿科健康结果至关重要.
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