对固定和基于体重的四因素前列红素复合物缩剂剂量方案的结果进行比较
Amal Bittar1, Carl Zipperlen2, Gregory Gilbert3
1Pharmacy, Mount Sinai South Nassau, Oceanside, New York, USA amalbittar10@gmail.com.
European journal of hospital pharmacy : science and practice
|September 19, 2023
概括
固定的剂量四因子前列红素复合缩物 (4F-PCC) 提供与基于体重的剂量相比的血液静止. 固定的治疗方案还可以提供更快的治疗时间,而不会影响出血患者的死亡率.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 越来越多地使用固定的剂量方案为四因子前激素复合缩物 (4F-PCC),但与基于体重的剂量相比,它们的疗效需要进一步研究.
- 对于4F-PCC用于各种出血类型和抗凝固剂的"一刀切"方法存在不确定性.
研究的目的:
- 为了比较固定剂量和基于体重的剂量之间的血液静止的实现,4F-PCC疗法.
- 评估两种剂量策略之间的给药时间和住院死亡率之间的差异.
主要方法:
- 追溯队列研究,包括接受4F-PCC治疗大出血的成年患者,治疗华法林或Xa因子抑制剂.
- 固定剂量 (治疗) 与基于体重的剂量 (比较剂量) 的比较 4F-PCC疗法.
- 排除标准包括非紧急手术,未知出血源,未服用抗凝血剂的患者,肝功能衰竭,大比加特兰使用或肝素过敏.
主要成果:
- 在固定剂量 (45%) 和基于体重的剂量 (46%) 组之间,血静达到的统计学上没有显著差异 (p=0.872).
- 固定的剂量4F-PCC的使用速度明显更快 (32分 vs 46分,p=0.031).
- 医院住院死亡率在两组之间是相似的 (29%对29%,p=0.968).
结论:
- 固定的剂量4F-PCC疗法表现出与基于体重的疗法相似的静血结局.
- 固定的剂量有助于更快的施用时间,这是管理重大出血事件的关键因素.
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