具有强大的抗菌性质和细胞相容性的聚乙烯 (乙烯基模醇) 衍生物的结构异质的两连接网络
Arka Biswas1,2, Arvind K Singh Chandel3, Anuradha1,2
1Membrane Science and Separation Technology Division, Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), G. B. Marg, Bhavnagar, Gujarat 364002, India.
ACS applied materials & interfaces
|September 19, 2023
概括
两性网 (APCN) 表面通过将脂性基基团从阴离子网络分离出来,显示出强烈的抗微生物和抗生物膜活性. 这些表面有效地破坏细菌细胞,为评估生物杀菌性质提供了一个有希望的模型.
科学领域:
- 材料科学 材料科学 材料科学
- 表面化学 表面化学
- 生物技术是生物技术.
背景情况:
- 开发具有抗微生物特性的表面对于预防感染至关重要.
- 现有的抗微生物策略经常面临有效性和生物相容性方面的挑战.
研究的目的:
- 构建基于两性网 (APCN) 的表面,具有强大的抗微生物和生物膜抑制能力.
- 研究APCN的结构与其生物杀菌活性之间的关系.
主要方法:
- 通过与活性化物化合物反应部分化聚 (?? 乙烯胺) 合成APCN表面.
- 涂层玻璃和聚二甲基 (PDMS) 板与APCN.
- 评估的胀,机械特性,相位形态,细菌细胞破坏,以及最小的抑制量.
主要成果:
- APCN涂层表现出更长的基链 (C6-C18) 的细菌细胞破坏力增加,对大肠杆菌有更大的疗效.
- 最低的抑制剂量在0.02-0.04mg/cm2之间,取决于基链长度和四级化程度.
- APCN显示出强大的生物杀伤活性,具有良好的血红相容性和细胞相容性.
结论:
- 基于APCN的表面具有有效的抗微生物和抗生物膜特性.
- APCN的设计允许基于结构修改的可调节的生物杀菌活性.
- 这些APCN作为一种有价值的模型,用于在抗菌材料中的结构-活性关系研究.
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