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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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维生素E治疗改善了透析患者的抗氧化能力:系统性审查和元分析
Ce Ni1, Wenhua Zhou1, Mengyuan Yu1
1Department of Nephrology, The Second Hospital of Jilin University, 218 Zi-Qiang Street, Changchun, Jilin, 130000, China.
Molecular nutrition & food research
|September 19, 2023
概括
维生素E治疗,包括维生素E涂层的透析膜和口服补充剂,可以提高透析患者的抗氧化剂水平. 这改善了诸如超氧化物脱酶和酶之类的关键标记物,特别是在血液透析患者中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 生物化学 生物化学
- 抗氧化剂研究 抗氧化剂研究
背景情况:
- 透析患者经常经历氧化应激.
- 抗氧化剂分子在缓解细胞损伤方面发挥着至关重要的作用.
研究的目的:
- 评估维生素E干预措施对透析患者抗氧化剂水平的影响.
- 评估维生素E涂层透析膜 (VEM) 和口服维生素E补充剂的疗效.
主要方法:
- 这是一项包括24项涉及512名透析患者的研究的综合元分析.
- 在PubMed,Embase,CNKI和Cochrane图书馆数据库中进行文学搜索.
主要成果:
- 长期VEMs治疗在血液透析 (HD) 患者中显著增加了抗氧化剂标志物.
- 口服维生素E的摄入显著提高了红细胞衍生型超氧化溶解酶 (SOD),谷氨过氧化酶 (GPX) 和催化酶 (CAT) 的水平.
- 维生素E没有显著影响腹透析 (PD) 患者的抗氧化剂水平.
结论:
- 维生素E疗法在透析患者中对维持抗氧化化合物的有益作用.
- VEMs和口服维生素E是改善HD患者抗氧化状态的有效策略.
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