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Updated: Jul 16, 2025

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research
09:07

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research

Published on: July 12, 2024

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通过PAI-1降解,CSE降低了OTUD4,触发了通过PAI-1降解的肺上皮细胞亡

Lijuan Luo1,2,3, Tiao Li1,2,3, Zihang Zeng1,2,3

  • 1Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.

Cell death & disease
|September 19, 2023
PubMed
概括

卵巢瘤二维基因酶4 (OTUD4) 通过稳定等离子体激活剂抑制剂1 (PAI-1) 来保护呼吸道细胞免受香烟烟雾的破坏. 这种相互作用可以防止细胞亡和肺气,这表明了治疗点.

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Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy15:55

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